Indus Impex

Naltrexone Hydrochloride Tablets 25 mg IP – Opioid Antagonist for Addiction Treatment

Product Name: Naltrexone Hydrochloride Tablets IP
Strength: 25 mg
Form: Oral Tablet
Active Ingredient: Naltrexone Hydrochloride
Pack Size: Typically available in 10 tablets per strip or as per customer requirement
Manufacturer / Exporter: Indus Impex
Therapeutic Category: Opioid Antagonist / Anti-Addiction Medicine

Product Overview:

Naltrexone Hydrochloride 25 mg is a centrally acting opioid receptor antagonist used in the treatment of opioid dependence and alcohol use disorder. It works by blocking the euphoric and sedative effects of opioids and alcohol, reducing cravings and preventing relapse. Naltrexone is non-addictive and does not cause physical dependence, making it a valuable tool in long-term recovery programs.

This formulation complies with Indian Pharmacopoeia (IP) standards, ensuring consistent quality and safety.

Indications:

• Maintenance therapy in opioid dependence

• Supportive treatment in alcohol dependence

• Prevents relapse in detoxified opioid/alcohol-dependent patients

Mechanism of Action:

Naltrexone competitively binds to mu, kappa, and delta opioid receptors in the brain, preventing opioids from activating them. It also helps reduce the reinforcing effects of alcohol, possibly by modulating the mesolimbic dopamine system.

Dosage & Administration:

• Typical adult dose:
  25 mg once daily as a test dose
  If tolerated, may be increased to 50 mg once daily

• Must be started after detoxification from opioids (typically 7–10 days opioid-free)

Note: Treatment should be initiated under medical supervision.

Precautions:

• Ensure the patient is opioid-free before starting therapy (risk of acute withdrawal)

• Use with caution in patients with liver disease – monitor liver enzymes

• Not recommended during pregnancy or breastfeeding unless necessary

• Avoid in acute hepatitis or liver failure

Side Effects:

Common:

• Nausea

• Headache

• Dizziness

• Fatigue

• Anxiety

Serious (rare):

• Hepatotoxicity (dose-dependent)

• Depression or suicidal thoughts (monitor mood changes)

Contraindications:

• Current opioid use or dependence

• Positive urine opioid test

• Acute liver disease

• Known hypersensitivity to naltrexone

Storage Instructions:

• Store in a cool, dry place below 25°C

• Protect from light and moisture

• Keep out of reach of children

Regulatory & Export Details:

• Prescription-only medicine (Rx)

• Manufactured under GMP and WHO guidelines

• Available for export to markets where approved under applicable drug regulations

• Custom packaging and branding available for bulk orders

Disclaimer:

This product should only be used under the guidance of a qualified healthcare provider. Indus Impex does not promote self-medication or unauthorized usage. The information provided here is for educational and regulatory reference purposes only.

Promethazine used in the treatment of nausea and vomiting related to certain conditions like before/after surgery or motion sickness.Monagran Promethazine Syrup contains promethazine, a first-generation antihistamine used to treat various conditions.

Uses:

• Allergy Relief: Alleviates symptoms such as itching, runny nose, sneezing, and hives. citeturn0search0

• Nausea and Vomiting: Prevents and controls nausea and vomiting related to motion sickness or post-surgery. citeturn0search1

• Sedation: Used as a sedative or sleep aid before or after surgical procedures. citeturn0search4

Dosage and Administration:

• Follow your healthcare provider's instructions regarding dosage.

• Use a proper measuring device to ensure accurate dosing. citeturn0search7

Potential Side Effects:

• Common: Drowsiness, dizziness, dry mouth, blurred vision. citeturn0search7

• Serious: Respiratory depression, especially in children under two years old; severe allergic reactions; neuroleptic malignant syndrome. Seek immediate medical attention if serious side effects occur. citeturn0search2

Precautions:

• Children: Not recommended for use in children under two years due to the risk of severe respiratory depression. citeturn0search2

• Elderly: Use with caution, as older adults may be more sensitive to side effects like confusion and drowsiness. citeturn0search17

• Medical Conditions: Inform your doctor if you have breathing problems, glaucoma, heart disease, liver disease, or other significant health issues. citeturn0search7

• Alcohol: Avoid consuming alcohol, as it can enhance drowsiness and dizziness. citeturn0search7

Note: Always consult with a healthcare professional before using Monagran Promethazine Syrup to ensure it's appropriate for your condition and to understand the correct dosage and potential risks.

Product Name: Low Dose Naltrexone Capsules

Available Strengths: 1.5 mg | 3 mg | 4.5 mg
Form: Oral Capsules
Active Ingredient: Naltrexone Hydrochloride (Low Dose)
Pack Size: Customizable (e.g., 30 capsules per bottle or as per client requirement)
Manufacturer / Exporter: Indus Impex
Therapeutic Category: Immune Modulator / Off-Label Therapy

Product Overview:

Low Dose Naltrexone (LDN) is an emerging therapy used in microdoses ranging from 1.5 mg to 4.5 mg to modulate the immune system and reduce inflammation. While standard-dose Naltrexone (50 mg) is used to treat opioid and alcohol dependence, LDN is used off-label for a variety of chronic autoimmune and inflammatory conditions.

LDN works by temporarily blocking opioid receptors, triggering an increase in the body’s production of endorphins and enkephalins, which are natural regulators of the immune response.

Key Applications (Off-Label):

• Multiple Sclerosis (MS)

• Fibromyalgia

• Chronic Fatigue Syndrome (CFS/ME)

• Crohn’s Disease & Ulcerative Colitis

• Hashimoto’s Thyroiditis

• Lupus

• Psoriasis & Eczema

• Cancer (as adjunct support)

• Long COVID support (emerging use)

Note: LDN is prescribed off-label in these conditions and should be used under a physician’s guidance.

Mechanism of Action:

• Temporarily blocks opioid receptors for a few hours daily

• This rebound effect leads to upregulation of endogenous opioids

• Enhances immune function and reduces pro-inflammatory cytokines

• Promotes homeostasis and tissue healing

Recommended Dosing:

• Start with 1.5 mg at night, gradually increasing to 3 mg and then 4.5 mg if tolerated

• Best taken at bedtime to align with endorphin cycles

• Dosage and progression to be supervised by a medical professional

Advantages of LDN Therapy:

• Non-toxic, well-tolerated at low doses

• Minimal risk of dependence or sedation

• No narcotic effects

• Inexpensive adjunct to chronic condition management

Side Effects (Mild & Temporary):

• Vivid dreams or sleep disturbances

• Headache

• Nausea

• Anxiety (rare and transient)

Most side effects resolve as the body adjusts to the dose.

Precautions:

• Avoid concurrent use of opioid pain medications (e.g., morphine, tramadol)

• Not suitable for patients actively dependent on opioids

• Use in pregnancy and breastfeeding only under medical advice

Storage Conditions:

• Store below 25°C in a dry, cool place

• Protect from moisture and sunlight

• Keep out of reach of children

Regulatory & Export Information:

• LDN is an off-label use of approved Naltrexone Hydrochloride

• Export available for research use, compounding pharmacies, or private clinics under local regulations

• Custom labeling, branding, and packaging available

• Manufactured under GMP, WHO-GMP standards

It is used in cattle, sheep, goat for the treatment of infestation with gastrointestinal nematodes, lungworms and tapeworms.

Product Name:

Progesterone Soft Gelatin Capsules 200 mg

General Description:

Progesterone Soft Gelatin Capsules 200 mg are a hormonal medication used for various gynecological and obstetric applications. These capsules contain micronized natural progesterone, a hormone essential for regulating ovulation, menstruation, and maintaining pregnancy. The formulation in a soft gelatin capsule ensures better absorption and gastrointestinal tolerance compared to other oral forms.

Composition:

• Active Ingredient: Natural Micronized Progesterone – 200 mg

• Form: Soft Gelatin Capsules

• Color: Usually opaque/light yellow (may vary)

Uses and Indications:

These capsules are prescribed in a wide range of conditions including:

• Luteal phase support in assisted reproductive technology (ART) cycles

• Hormone Replacement Therapy (HRT) in menopausal and perimenopausal women (in combination with estrogens)

• Treatment of secondary amenorrhea (absence of menstrual periods)

• Support during early pregnancy, particularly in women with a history of recurrent miscarriage or luteal phase defects

• Management of premenstrual syndrome (PMS) and irregular menstrual cycles

• Endometrial protection in women taking estrogen therapy

Mechanism of Action:

Progesterone prepares the endometrium (lining of the uterus) for implantation of a fertilized egg and maintains it during pregnancy. It also helps regulate the menstrual cycle and reduces the risk of endometrial hyperplasia caused by estrogen.

Dosage & Administration:

• Dosage varies based on the indication and patient condition.

• Typically taken once or twice daily as prescribed by a healthcare provider.

• Should be swallowed whole with water.

• Can be taken orally or used vaginally as directed by a physician.

Packing Details:

• Pack Size: 1 x 10 Capsules (Blister Pack)

• Packaging Type: Aluminium-PVC Blister Strip in a printed carton

• Carton Dimensions: Customizable based on export needs

• Manufacturer: Healing Pharma, India

• Exporter: Indus Impex

• Shelf Life: 36 Months from the date of manufacture

• Storage: Store in a cool, dry place below 25°C. Protect from direct sunlight and moisture.

Target Markets:

• Gynecology clinics

• Fertility centres

• Pharmaceutical distributors and importers

• Hospitals and healthcare providers

Arteeglo 100 mg Tablets

Arteeglo 100 mg tablets contain artesunate, an antimalarial medication used to treat uncomplicated cases of malaria caused by Plasmodium falciparum. citeturn0search0

Dosage and Administration:

• Dosage: The standard dosage involves taking 100 mg of artesunate daily for a specified duration, often in combination with other antimalarial agents, as prescribed by a healthcare professional.

• Administration: The tablets should be taken with food to enhance absorption. If vomiting occurs within 30 minutes of dosing, the full dose should be repeated; if within 30–60 minutes, half the dose should be repeated.

Potential Side Effects:

• Common side effects may include loss of appetite, dizziness, nausea, and diarrhea, particularly during the first two days of treatment.

• Serious side effects are rare but can include allergic reactions, hemoglobinuria, seizures, and neuropsychiatric reactions.

Precautions:

• Pregnancy and Breastfeeding: Consult a healthcare provider before use, as safety data in pregnant and breastfeeding women are limited.

• Drug Interactions: Inform your doctor of all medications you are taking, as artesunate may interact with other drugs.

• Underlying Conditions: Use with caution in patients with liver or kidney impairment.

Important Notes:

• Combination Therapy: Artesunate is often used in combination with other antimalarial drugs, such as amodiaquine, to enhance efficacy and prevent resistance. citeturn0search9

• Complete the Course: Ensure the full course of treatment is completed to prevent recrudescence and resistance development.

Always consult with a healthcare professional before starting treatment with Arteeglo 100 mg tablets to ensure it's appropriate for your specific condition and to receive personalized dosing and administration instructions.

Triclabendazole 500 mg Tablets – Broad-Spectrum Anthelmintic for Liver Fluke Infections

Product Name: Triclabendazole Tablets 500 mg
Active Ingredient: Triclabendazole 500 mg
Form: Oral Tablet
Therapeutic Class: Anthelmintic (Anti-parasitic)
Pack Size: Customizable (typically 2–6 tablets per strip or as required)
Manufacturer/Exporter: Indus Impex

Product Overview:

Triclabendazole 500 mg is a highly effective anthelmintic drug primarily used for the treatment of fascioliasis (liver fluke infections) in both humans and animals. It is effective against both immature and adult flukes, making it the drug of choice in treating Fasciola hepatica and Fasciola gigantica infections.

This medication is included on the World Health Organization’s List of Essential Medicines and is approved for human use in several countries under prescription.

Indications:

• Fascioliasis (liver fluke infection)

• Parasitic flatworm infections affecting the liver and bile ducts

• Used in both human and veterinary applications (under separate protocols)

Mechanism of Action:

Triclabendazole disrupts the microtubular structure and enzyme activity within the liver fluke, inhibiting its motility and survival. It is absorbed systemically and acts on both immature and adult stages of the parasite.

Dosage & Administration:

• Standard adult dosage:
  10 mg/kg body weight as a single dose
  OR
  10 mg/kg twice, 12 hours apart (as recommended in resistant cases)

• To be taken with food to improve absorption

• Veterinary dosage to be determined by a veterinarian

Precautions:

• For oral use only

• Not recommended for patients with severe liver impairment

• Caution in pregnancy (especially first trimester) unless benefits outweigh risks

• Monitor liver function in long-term use or high parasite load cases

Side Effects:

Common:

• Abdominal pain

• Nausea

• Headache

• Fatigue

Rare:

• Elevated liver enzymes

• Allergic skin reactions

• Biliary colic due to dead parasite obstruction

Storage Instructions:

• Store in a cool, dry place below 25°C

• Protect from moisture and direct sunlight

• Keep out of reach of children

Regulatory Information:

• Prescription-only medicine in most countries

• WHO-listed essential medicine for parasitic infections

• Export available for human or veterinary use depending on local regulations

• GMP/WHO certified manufacturing standards

Disclaimer:

This product is intended for use under medical supervision only. Indus Impex does not endorse unsupervised or unapproved usage of any anthelmintic. All usage instructions should follow local drug regulations and physician or veterinarian guidelines.

Product Name: Tolvaptan 30mg Tablets
Manufacturer: Healing Pharma
Composition: Tolvaptan 30mg
Packaging:

• Strip: 1 x 10 Tablets

• Box: 10 Strips (Total 100 Tablets per Box)
  Availability: Export Only – Supplied by Indus Impex

Product Description:

Tolvaptan 30mg is a vasopressin V2-receptor antagonist indicated for the treatment of hyponatremia (low blood sodium levels) associated with conditions such as syndrome of inappropriate antidiuretic hormone secretion (SIADH), and for autosomal dominant polycystic kidney disease (ADPKD) in certain cases.

Manufactured by Healing Pharma, this high-quality formulation offers effective management of fluid imbalance by promoting free water excretion without electrolyte loss, helping to restore and maintain sodium balance in the body.

Key Features:

• Active Ingredient: Tolvaptan 30mg – a selective vasopressin receptor antagonist

• Primary Use: Treatment of clinically significant hyponatremia and polycystic kidney disease

• Convenient Packaging: 10 tablets per strip; 10 strips per box (100 tablets total)

• Quality Assured: GMP-certified production by Healing Pharma

• Secure Blister Pack: Ensures long shelf life and product safety during transport

Indications:

• Hyponatremia due to SIADH

• Autosomal Dominant Polycystic Kidney Disease (ADPKD)

• Fluid retention associated with certain heart, liver, and kidney conditions (as prescribed)

Dosage & Administration:

Should be taken as directed by a healthcare professional. Treatment usually begins under medical supervision due to the risk of rapid sodium correction.

Storage Instructions:

• Store below 30°C in a cool, dry place

• Protect from moisture and direct sunlight

• Keep out of reach of children

Export Information:

Tolvaptan 30mg Tablets by Healing Pharma are available for export through Indus Impex in blister packs of 1x10 tablets, with 100 tablets per box. Custom labeling and bulk supply options are available upon request.

Spironolactone 25 mg is a medication primarily used to treat conditions related to fluid retention and hormonal imbalances.

Uses:

• Edema: Manages fluid retention associated with conditions like heart failure, liver cirrhosis, and nephrotic syndrome.

• Hypertension: Helps lower high blood pressure, reducing the risk of strokes and heart attacks.

• Heart Failure: Improves survival and reduces hospitalizations in certain heart failure patients.

• Hyperaldosteronism: Treats primary hyperaldosteronism by counteracting excessive aldosterone production.

• Hormonal Acne and Hirsutism: Used off-label to address acne and excessive hair growth in women by blocking androgen effects.

Dosage:

• Edema: Typically, 25–200 mg per day, administered in single or divided doses.

• Hypertension: Starting dose is often 50–100 mg daily, which may be adjusted based on response.

• Heart Failure: Commonly initiated at 25 mg once daily.

• Hormonal Acne and Hirsutism: Doses range from 50–200 mg daily, depending on severity and response.

Potential Side Effects:

• Common:

  • Dizziness or lightheadedness

  • Nausea or vomiting

  • Headache

  • Breast tenderness or enlargement

  • Menstrual irregularities

• Serious:

  • Hyperkalemia (elevated potassium levels), which can be life-threatening

  • Severe allergic reactions

  • Kidney dysfunction

  • Electrolyte imbalances

Precautions:

• Kidney Function: Regular monitoring is essential, especially in those with existing kidney issues.

• Potassium Levels: Avoid potassium supplements and potassium-rich foods to prevent hyperkalemia.

• Pregnancy and Breastfeeding: Consult a healthcare provider, as spironolactone may not be recommended.

• Other Medications: Inform your doctor about all medications being taken to avoid potential interactions.

Administration Tips:

• Take with or without food; if stomach upset occurs, consume with food.

• Maintain consistent daily timing for doses.

• If a dose is missed, take it as soon as remembered unless it's near the time for the next dose; do not double up doses.

Always follow your healthcare provider's instructions regarding spironolactone use to ensure safety and effectiveness.

Tranexamic Acid Tablets USP, 500 mg

Description:

Tranexamic Acid is an antifibrinolytic agent that helps reduce or prevent excessive bleeding by inhibiting the breakdown of blood clots. It is commonly prescribed for conditions involving heavy bleeding such as heavy menstrual bleeding (menorrhagia), nosebleeds (epistaxis), dental surgeries in patients with bleeding disorders, and surgical bleeding.

Each tablet contains 500 mg of tranexamic acid for oral use.

Appearance:

• Color: White or off-white

• Shape: Round or oval (depends on manufacturer)

• Markings: May have identifying letters/numbers and may be scored for splitting.

Active Ingredient:

• Tranexamic Acid USP – 500 mg

Inactive Ingredients (may vary by manufacturer):

• Microcrystalline cellulose

• Magnesium stearate

• Povidone

• Colloidal silicon dioxide

• Crospovidone

• Hypromellose

• Titanium dioxide

• Polyethylene glycol

(Specific ingredients can vary slightly based on brand.)

Pharmacological Class:

• Antifibrinolytic Agent

Mechanism of Action:

Tranexamic acid works by blocking the binding of plasminogen to fibrin, thereby preventing the breakdown of fibrin clots. This stabilizes the clot and helps reduce bleeding.

Indications and Usage:

• Treatment of heavy menstrual bleeding (menorrhagia)

• Prevention and treatment of bleeding after dental surgery (especially in hemophiliacs)

• Management of nosebleeds (epistaxis)

• Control of surgical bleeding

• Treatment of bleeding in trauma cases (as per hospital protocol)

Dosage:

• Common adult dose for heavy menstrual bleeding: 500 mg to 1000 mg three times daily for up to 5 days during menstruation.

• Dosing depends on the type and severity of bleeding and must follow the doctor's recommendation.

Administration:

• Taken by mouth, usually with or without food.

• Swallow tablets whole with a glass of water.

• It is best taken at the first sign of bleeding for maximum effectiveness.

Warnings and Precautions:

• Should not be used in patients with active intravascular clotting.

• Caution in patients with a history of thromboembolic disease (e.g., DVT, pulmonary embolism).

• Use with care in patients with kidney problems (dose adjustment may be needed).

• Rare risk of vision changes — regular eye exams recommended for long-term use.

Common Side Effects:

• Nausea

• Vomiting

• Diarrhea

• Muscle cramps

• Headache

Serious Side Effects (Seek immediate medical attention):

• Vision problems (changes in color vision, blurred vision)

• Symptoms of blood clots (leg swelling, chest pain, shortness of breath)

• Severe allergic reactions (rash, itching, swelling)

Storage:

• Store at 20°C to 25°C (68°F to 77°F).

• Keep away from moisture and light.

• Store in a tightly closed container.

• Keep out of reach of children.

Packaging:

• Typically available in blister packs or bottles of 10, 30, 100, or more tablets.